Short presentation
Dr. Kawthar BOUCHEMAL is an associate professor of Pharmaceutical Technology at the UMR CNRS 8612 headed by Pr. Elias FATTAL (Université Paris Sud - Châtenay-Malabry, France).
Her main topics of interest are designed to address challenges for:
(i) the entrapment of poorly absorbed molecules,
(ii) to make them bypass natural barriers and
(iii) to ensure their targeting into biological tissues.
Peer-reviewed articles and book chapters
[43] Mazzaferro S, Bouchemal K*, Skanji R, Gueutin C, Chacun H, Ponchel G. Intestinal permeation enhancement of docetaxel encapsulated into methyl-β-cyclodextrin/poly(isobutylcyanoacrylate) nanoparticles coated with thiolated chitosan. Submitted. 2012.
[42] Mazzaferro S, Bouchemal K*, Ponchel G. Oral delivery of anti-cancer drugs I: General considerations. Submitted. 2012.
[41] Mazzaferro S, Bouchemal K*, Ponchel G. Oral delivery of anti-cancer drugs II: The prodrug strategy. Submitted. 2012.
[40] Mazzaferro S, Bouchemal K*, Ponchel G. Oral delivery of anti-cancer drugs III: Formulation of anti-cancer drugs using drug delivery systems. Submitted. 2012.
[39] Mazzaferro S, Maksimenko A, Skanji R, Bouchemal K*, Opolon P, Ponchel G. Reduced intestinal toxicity of docetaxel loaded into methyl-β-cyclodextrin/poly(isobutylcyanoacrylate) mucoadhesive nanoparticles coated with thiolated chitosan, in mouce xenograft model. Submitted. 2012.
[38] Zhang M, Djabourov M, Bouchemal K*. Nanostructured fluids from pluronic mixtures. Submitted. 2012.
[37] Mitri K, Vauthier C, Menas A, Huang N, Ringard C, Anselmi C, Stambouli M, Rosilio V, Vachon J-J, Bouchemal K*. Scale-up of nano-emulsion produced by spontaneous emulsification and solvent diffusion. Submitted. 2012.
[36] Bouchemal K*, Mazzaferro S. How to conduct and interpret accurately ITC experiments for the cyclodextrin-guest interactions? Drug Discov Today. 2012. Accepted for publication.
[35] Hassani L. N, Hendra F, Bouchemal K*. Intérêt des polysaccharides amphiphiles auto-associatifs dans la vectorisation de médicaments. Actualité Chimique. 2012. Accepted for publication.
[34] Hassani L. N, Hendra F, Bouchemal K*. Auto-associative amphiphilic polysaccharides as drug delivery systems. Drug Discov Today. 2012. Accepted for publication.
[33] Petit B, Bouchemal K*, Vauthier C, Djabourov M, Ponchel G. The counterbalanced effect of size and surface properties of chitosan-coated poly(isobutylcyanoacrylate) nanoparticle on mucoadhesion due to pluronic F68 addition. Pharm Res. 2012, DOI10.1007/s11095-011-0634-z. 
[32] Hanno I, Anselmi C, Bouchemal K*. Polyamide nanocapsules and nano-emulsions containing Parsol MCX and Parsol 1789: in vitro release, ex vivo skin penetration and photo-stability studies. Pharm Res. 2012, 29(2), 559-573. DOI: 10.1007/s11095-011-0592-5.
[31] Vauthier C, Bouchemal K. Processing ans scale-up of polymeric nanoparticles. In Prokop A (ed). Intracellular Delivery: Fundamentals and Applications, Fundamental Biomedical Technologies 5, DOI 10.1007/978-94-007-1248-5_16. Springer, 2011, p433-456.
[30] Ozcan I*, Bouchemal K, Segura-Sánchez F, Ozer O, Güneri T, Ponchel G. Synthesis and Characterization of surface-modified PBLG nanoparticles for bone targeting: In vitro and in vivo evaluation. J Pharm Sci. 2011, 100(11), 4877-4887. DOI: 10.1002/jps.22678.
[29] Mazzaferro S*, Bouchemal K, Gallard J-F, Iorga B I, Cheron M, Gueutin C, Steinmesse C, Ponchel G. Bivalent sequantial binding of docetaxel to methyl-β-cyclodextrin. Int J Pharm. 2011, 416(1), 171-180. DOI: 10.1016/j.ijp.2011.06.034.
[28] Othman M, Bouchemal K, Couvreur P, Desmaële D, Morvan E, Pouget T, Gref R*. A comprehensive study of the spontaneous formation of nanoassemblies in water by a "Lock-and-Key" interaction between two associative polymers. J Colloid Interf Sci. 2011, 354, 517-527. DOI: 10.1016/j.jcis.2010.11.015.
[27] Mazzaferro S, Bouchemal K*, Vauthier C, Gueutin C, Palmieri G-F, Ponchel G. What are parameters affecting Leu-enkephalin loading and release from poly(isobutylcyanoacrylate) nanoparticles coated with thiolated chitosan? J Drug Del Sci Tech. 2011, 21(5), 385-393.
[26] Ozcan I*, Segura-Sánchez F, Bouchemal K, Sezak M, Ozer O, Güneri T, Ponchel G. Pegylation of poly(g-benzyl-L-glutamate) nanoparticles is efficient for avoiding mononuclear phagocyte system capture in rats. Int J Nanomed. 2010, 5, 1103–1111. DOI: 10.1007/s11095-011-0592-5
[25] Sajeesh S, Bouchemal K, Vauthier C, Chandra P Sharma*. Cyclodextrin complexed insulin encapsulated hydrogel microparticles: an oral delivery system for insulin. J Control Release. 2010, 147, 377-384. DOI:/ 10.1016/j.jconrel.2010.08.007.
[24] Daoud-Mahammed S# Agnihotril S#, Bouchemal K, Klöters S, Couvreur P, Gref R*. Efficient loading and controlled release of benzophenone-3 entrapped into self-assembling nanogels. Curr Nanosci. 2010, 6, 1-12.
#equally contributing authors.
[23] Aka-Any-Grah A, Bouchemal K*, Koffi A, Agnely F, Zhang M, Djabourov M, Ponchel G. Formulation of mucoadhesive vaginal hydrogels insensitive to dilution with vaginal fluids. Eur J Pharm Biopharm. 2010, 76, 296-303. DOI: 10.1016/j.ejpb.2010.07.004.
[22] Sajeesh S, Bouchemal K, Chandra P Sharma, Vauthier C*. Surface functionalized polymethacrylate acid based hydrogel microparticles for oral drug delivery. Eur J Pharm Biopharm. 2010, 74(2), 209-218. DOI: 10.1016/j.ejpb.2009.09.001.
[21] Pilloni M, Nicolas J*, Marsaud V, Bouchemal K, Frongia F, Scano A, Ennas G, Dubernet C. PEGylation and preliminary biocompatibility evaluation of magnetite-silica nanocomposites obtained by high energy ball milling. Int J Pharm. 2010, 401 (1-2), 103-112. DOI: 10.1016/j.ijpharm.2010.09.010.
[20] Segura-Sanchez F, Montembault V, Fontaine L, Martinez-Barboza Ma.E, Bouchemal K, Ponchel G*. Synthesis and Characterization of functionalized poly(γ-benzyl-L-glutamate) derivates and corresponding nanoparticles preparation and characterization. Int J Pharm. 2010, 1-2, 244-252. DOI: 10.1016/j.ijpharm.2009.12.016.
[19] Bouchemal K*, Agnely F, Koffi A, Djabourov M, Ponchel G. What can isothermal titration microcalorimetry experiments tell us about self-organization of surfactants into micelles? J Mol Recognit. 2010, 22 (4), 235-242. DOI: 10.1002/jmr.998.
[18] Bouchemal K*, Couvreur P, Daoud-Mahammed S, Poupaert J, Gref R. A comprehensive study on the inclusion mechanism of benzophenone into supramolecular nanoassemblies prepared using two water-soluble associative polymers. J Therm Anal Calorim. 2009, 98, 57-64. DOI: 10.1007/s10973-009-0452-2.
[17] Agüeros M, Ruiz-Gatón L, Vauthier C, Bouchemal K, Espuelas S, Ponchel G, Irache JM*. Combined hydroxypropyl-β-cyclodextrin and poly(anhydride) nanoparticles improves the oral permeability of paclitaxel. Eur J Pharm Biopharm. 2009, 38(4), 405-413. DOI: 10.1016/j.ejps.2009.09.010.
[16] Özcan I*, Bouchemal K, Segura-Sánchez F, Abaci Ö, Özer Ö, Güneri T, Ponchel G. Effects of sterilization techniques on the PEGylated poly (γ-benzyl-L-glutamate) (PBLG) nanoparticles. Acta Pharmaceutica Sciencia. 2009, 51, 211-218.
[15] Bouchemal K*, Agnely F, Koffi A, Ponchel G. A concise analysis of the effect of temperature and propanediol-1,2 on Pluronic F-127 micellization using isothermal titration microcalorimetry. J Colloid Interf Sci. 2009, 338, 169-176. DOI: 10.1016/j.jcis.2009.05.075.
[14] Othman M, Bouchemal K*, Couvreur P, Gref R. Microcalorimetric investigation on the formation of supramolecular nanoassemblies of associative polymers loaded with gadolinium chelate derivatives. Int J Pharm. 2009, 379, 218-225. DOI: 10.1016/j.ijpharm.2009.05.061.
[13] Roques C, Bouchemal K, Ponchel G, Fromes Y, Fattal E*. Parameters affecting organization and transfection efficiency of amphiphilic copolymer/DNA carriers. J Control Release. 2009, 138(1), 71-77. DOI: 10.1016/j.jconrel.2009.04.030.
[12] Daoud-Mahammed S, Couvreur P, Bouchemal K, Chéron M, Lebas G, Amiel C, Gref R*. Cyclodextrin and polysaccharide-based nanogels: entrapment of two hydrophobic molecules, benzophenone and tamoxifen. Biomacromolecules. 2009, 10(3), 547-554. DOI: 10.1021/bm801206f.
[11] Segura-Sanchez F, Bouchemal K*, Lebas G, Vauthier C, Santos-Magalhaes N.S and Ponchel G. Elucidation of the complexation mechanism between (+)-usnic acid and cyclodextrins studied by isothermal titration calorimetry and phase-solubility diagram experiments. J Mol Recognit. 2009, 22, 232-241. DOI: 10.1002/jmr.936.
[10] Vauthier C*, Bouchemal K. Methods for the preparation and manufacturing of polymeric nanoparticles. Pharm Res. 2009, 26(5), 1025-1058. DOI : 10.1007/s11095-008-9800-3.
[9] Bouchemal K*, Ponchel G, Mazzaferro S, Campos-requena V-H, Gueutin C, Palmieri G-F, Vauthier C. A new approach to determine loading efficiency of Leu-enkephalin in poly(isobutylcyanoacrylate) nanoparticles coated with thiolated chitosan. J Drug Del Sci Tech. 2008, 18 (6), 392-397.
[8] Bouchemal K*. New challenges for pharmaceutical formulations and drug delivery system characterization using isothermal titration calorimetry. Drug Discov Today. 2008, 13 (21-22), 960-972. DOI: 10.1016/j.drudis.2008.06.004.
[7] Campos-Requena V-H*, Bouchemal K, Vauthier C, Ponchel G. Encapsulation of leu-enkephalin in core-shell poly(isobutylcyanoacrylate)-thiolated chitosan nanoparticles for oral administration. J Chil Chem Soc. 2008, 54 (3), 1677-1681.
[6] Bouchemal K*, Couenne F, Briançon S, Fessi H, Tayakout M. Stability studies on colloidal
suspensions of Polyurethane nanocapsules. J Nanosci Nanotechno. 2006, 6 (9-10), 3187-3192. DOI: 10.1166/jnn.2006.468.
[5] Bouchemal K, Couenne F*, Briançon S, Fessi H, Tayakout M. Polyamides nanocapsules: modelling and wall thickness estimation. AIChE J. 2006, 52 (6), 1-10. DOI: 10.1002/aic.10828.
[4] Bouchemal K, Briançon S, Fessi H, Chevalier Y*, Bonnet I, Perrier E. Simultaneous emulsification and interfacial polycondensation for the preparation of colloidal suspension of
nanocapsules. Mat Sci Eng. C. 2006, 26, 472-480. DOI: 10.1016/j.msec.2005.10.022.
[3] Bouchemal K*, Briançon S, Perrier E, Fessi H. Nano-emulsion formulation using spontaneous emulsification: Solvent, oil and surfactant optimization. Int J Pharm. 2004, 280 (1-2), 241-251. DOI: 10.1016/j.ijpharm.2004.05.016.
[2] Bouchemal K*, Briançon S, Perrier E, Fessi H, Bonnet I, Zydowicz N. Synthesis and characterization of polyurethane and poly(ether urethane) nanocapsules using a new technique of interfacial polycondensation combined to spontaneous emulsification. Int J Pharm. 2004, 269 (1), 89-100. DOI: 10.1016/j.ijpharm.2003.09.025.
[1] Bouchemal K, Briançon S, Chaumont P, Fessi H, Zydowicz N*. Microencapsulation of
Dehydroepiandrosterone (DHEA) with poly (ortho esters) polymers by interfacial polycondensation.
J Microencapsul. 2003, 20 (5), 635-651. DOI: 10.1080/026520403100014804.